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The new super meta review of Ivermectin is out. It’s 27 pages of fine print detail and 144 references, and it’s very impressive.
Ivermectin…. by Fvasconcellos
Bryant et al soaked themselves in 24 studies involving 3,406 people and found that ivermectin use reduced deaths by a very nice 60% with “moderate certainty”. But ivermectin appears to be at its best when used to prevent infections in the first place. There was “low certainty” but with prophylactic use Covid infections were reduced by an average of 86% . But by the time patients were “in need of mechanical ventilation”, the data, while muddy, suggested ivermectin was not much help.
The bad thing about Ivermectin is that there are not many bad things. It’s too good, too cheap, too safe, and too far out of patent to be profitable.
Given the evidence of efficacy, safety, low cost, and current death rates, ivermectin is likely to have an impact on health and economic outcomes of the pandemic across many countries. Ivermectin is not a new and experimental drug with an unknown safety profile. It is a WHO “Essential Medicine” already used in several different indications, in colossal cumulative volumes.
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History books will be written and some professors, academics, and bureaucrats will have no excuse.
Which organisations can serve now?
It took two court hearings and major complaints and assertive activism to save eighty year old Judy Smentkiewicz. But how many others died because their sons or daughters didn’t see Pierre Kory on TV? Or they didn’t have the wherewithal to go to court? Or their friends trying to share the message were censored on Facebook? It shouldn’t have to be this way.
This is Judy’s story below, but so much more. Read the whole thing. It’s very well written by Michael Capuzzo. Surely, this is a story that needs an answer. Where are the Forth Estate, the Opposition, The AMA, or the publicly funded professors at our universities?
I am but a cog passing on points of view that should be part of our national conversation. Some things matter: like antivirals and closed borders.
Nick Corbishley says “I don’t know of a bigger story in the world”
Michael Capuzzo, a New York Times best-selling author , has just published an article titled “The Drug That Cracked Covid”. … But unfortunately most reporters are not […]
Just another anti-viral
There was a good but small (tiny) study that came out of Israel three weeks ago about a drug called EXO-CD24. The professor in charge claims to have treated 30 out of 30 people who had moderate to severe cases and had near universal success. All, bar one, were able to leave hospital very quickly. CD24 is normally stuck on the outside of immune system cells. By getting EXO-CD in, apparently they can stop the cytokine storm.
Any day now, the mainstream media will let us know. The media may also mention that unlike vaccines the drug EXO-CD24 and according to Professor Nadir Arber, could be scaled up and mass produced within a few months and they could provide enough doses for the World.
Has Israel found the cure for Covid?
“To date, the preparation has been tried with great success on 30 severe patients, in 29 of whom the medical condition improved within two to three days and most of them were discharged home within three to five days. The 30th patient also recovered but after a longer time,” the hospital reports.
“The drug is based on exosomes, [vesicles] that […]
The STOIC study gave an asthma drug to Covid patients, but it worked so astonishingly well, they had to stop the trial early, as it was unfair to keep giving the placebo to people who were ending up in hospital ten times as often as people who got Budesonide.
“We were hoping for 50% reduction [in severity]. We got 90%, which … is off the charts”
–h/t Eric W at WUWT
Though to keep some perspective, out of about 140 people enrolled, 70 got the drug and 70 got the placebo, with 10 of the placebo group going to hospital and only 1 in the Budesonide group.
You’ll be shocked to know that giving the drug early works better than waiting for the virus to replicate wildly. You’ll also be shocked that there were some doctors using this 7 or more months ago, and yet the media didn’t mention it Apart from Newsmax. (Eg See Dr Richard Bartlett talk about this back in July last year, who talks of using a nebulizer, not an inhaler. )
Common asthma drug slashes Covid hospitalisation by 90%, experts say
Vanessa Chambers, The Sun
A […]
How many unnecessary deaths does it take til people get angry? Angry that the Chief Medical Officers and Health Ministers didn’t ask for studies to be done. Angry that most academics sat by and said nothing. And angry that the media just parroted the institutions.
One good antiviral changes everything. If the world had a safe cheap drug, we could not only reduce deaths and disability, but also slow the rate of mutation down and probably slow the appearance of new mutations down.
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The Chamie-Quintero study from Peru shows the West could be only weeks away from reducing the Covid death toll if we used the safe cheap sheep-dip, lice-killing Ivermectin like less wealthy countries do.
A study across the states of Peru found that after Ivermectin was introduced, deaths started to fall about 11 days later, and within a month after that, deaths were down around 75%.
Ivermectin is a drug so useful early researchers got a Nobel Prize in Medicine for work on it. It’s so well known that in the last thirty years more than 3.7 billion doses of Ivermectin have been given out. It’s so safe we can use it on cats […]
Some things matter. The biggest scandal of Covid — the one worth fighting for — is that there are drugs that work, which are safe and well tested, but they suffer from the crippling problem of being too cheap for our captured public health institutions to use. Because they are old safe, mass produced and out of patent no Pharmaceutical giant will make mass profits, which dooms them to being ignored, under researched, and generally scoffed at in rude dismissive terms.
The biggest failure of our government health agencies right now is the Black Hole of Medicine — the astronomical event horizon beyond which cheap safe drugs disappear without a trace.
3,000 people are dying every day in the USA and 5,000 a day are dying in Europe, mostly from a problem which can be solved to a large extent.
Sure, the media hate HCQ because “Donald”. But it’s not just HCQ and it’s not just Trump — the media ignore all the cheap antivirals and all the rich nations have the same medical Black Hole. This is the work of the Medical Swamp, captured by Big Pharma.
The Age of Antivirals is here and hardly anyone even knows […]
I didn’t think cough syrups even worked against coughs, but one new paper suggests that bromhexine in common cough syrups reduces both Covid-19 rates of ICU and of mortality.
The era of antivirals has come, not that Big Pharma want you to know that cheap out-of-patent drugs might help. But for years we were told that medical science didn’t have an answer to viruses.
Bromhexine was patented in 1961 and is commonly found in OTC pharmacy cough syrups with names like Bisolvon, Robitussin, and Duro-Tuss (Wiki has a long list).
Theoretically Bromhexine sabotages one of our molecules — with the snappy name of TMPRSS2 (which is shorter than saying Transmembrane protease S2). A protease is a fancy pair of molecular scissors, it chops or tweaks the viral spike and if that doesn’t happen, the virus can’t get into the cell (at least not through its favourite path).
The nice thing about an antiviral acting against our molecules, rather than against the virus itself, is that it’s harder for the virus to mutate to get around it. That means it’s less likely the virus can develop resistance. The downside of targeting our own molecules is that it might fritz things up. […]
The “Aeronabs” are on the way?
Right now there are more biomedical research teams focused on one problem than at any point in history, and they are armed. This is Biotech’s Big Moment, and here’s just another potential game changer. The time line here is short, and the ability to scale it is large. The seige of 2020 will end one way or another, and we will gain a whole set of tools to use on other viruses too.
If the virus has a key to get into our cells, this is like making millions of decoy locks that stick to the keys and thus disable them.
What if we could coat our lungs with tiny particles that work like PPE against coronavirus? The aim here is that one nasal spray a day might stop the virus getting entry into our cells. At the moment, one team have this working in the lab already. They’ve created a kind of cut down mini antibody, and at this stage it sticks like glue to the viral spikes. It still needs to be tested in humans, and might yet fall in a hole. But it’s another example of the potential contained […]
Lessons from Coronavirus
Lockdowns and border closures mean many diseases have been prevented
It’s peak season for flu here in Australia and there’s almost no sign of it. As Chris Gillham wrote here back in May, we know lockdowns stop viruses, because flu cases are 85% down. Now he shows that this extends to other diseases too, and Chris has used data from the National Notifiable Diseases Surveillance System to calculate that just shy of 200,000 fewer Australians contracted any of the notifiable diseases in the first seven months of 2020 compared to the first seven months of 2019.
Is some of that disease burden just the price of holiday-makers bringing back diseases from overseas each year?
No one wants to stop the planes returning to the skies, but it begs the question — do we have to accept the onslaught of winter germs every year?
The answer may lie with other things we’ve discovered in the Covid pandemic too — that sick people should stay home from work and school, and that we have a lot of anti-viral tools we can use. Perhaps it’s time that travellers considered taking preemptive anti-virals, which might improve their holidays and also reduce […]
The scandal from the Swamp: Too rich to get a cheap drug?
Poor countries all over the world are using Hydroxychloroquine (HCQ) and it appears to be very useful.
The new HCQTrial suggests that despite the billion dollar budgets and expert staff, people in wealthier countries are dying from Coronavirus at far higher rates than people are in lands where HCQ is being used. And the effect of HCQ apparently holds even after researchers correct for patients being older, heavier, with higher blood pressure, living in high density apartment towers, or with getting tested more.
If word ever gets out that the Politico-Academic-Corporate-Swamp buried useful drugs because they were unprofitable and out of patent, there will be hell to pay.
The HCQTrial was done anonymously by @CovidAnalysis — who say they are PhD researchers, scientists.
You can find our research in journals like Science and Nature. For examples of why we can’t be more specific search for “raoult death threats” or “simone gold fired”. We have little interest in adding to our publication lists, being in the news, or being on TV (we have done all of these things before but feel there are more important things in […]
Welcome to the Era of the Anti-Virals. They’re everywhere.
A legacy of the coronavirus pandemic is the dawn of new ways to stop viruses. Here’s another new (old) one — it’s only a small trial, but if it can stop 4 out of 5 people developing the severe form of the disease it will be a gamechanger. If this gets similar numbers on larger trials, then we still need mass production. But national policies will swing on a dime if a safe drug with this much potential appears.
After Coronavirus we might not be so content to accept the annual seasonal virus scourge.
Postenote: These are preliminary results, not a large trial, but at least it is placebo controlled and randomized.
Breakthrough’ treatment slashes virus death risk: study
by Patrick Galey, MedicalXpress
In a randomised trial of 100 patients admitted to hospital with COVID-19, those who received an inhaled formula of the protein interferon beta were at 79 percent lower risk of developing severe disease compared to those who received a placebo.
They were also more than twice as likely to make a full recovery compared with the control group.
The firm […]
Coronavirus may leave a trail of benefits in its wake. Who knew that there were so many cheap antivirals around? Will people get fed up with the limited choices on offer next time there is a quarantine.
While newspapers in Australia were pretty keen to share the discovery of an antiviral role for HCQ, not so many were interested in the followup studies.
Ivermectin, like hydroxychloroquine is a kind of superdrug — in the sense of being in worldwide mass use. Some 3.7 billion doses are estimated to have been given since its approval. It has been called the Japanese Wonder Drug. It’s the farm drench, a head lice treatment, and works against worm, mites and ticks too.
It was estimated to reduce viral loads in vitro massively but most people didn’t think it would work at lower safe doses. Then Bangladeshi doctors claim it was “astounding”. Last month US tests suggest that it reduced deaths by 40%. (Rajter)
These are all every priminary results. More studies are promised for Ivermectin. Especially in Peru, where a grassroots movement of Doctors has ensured it will be used.
A US clinical trial of the drug ivermectin found that it reduced […]
Good news on the HCQ front
The Henry Ford HCQ study is by no means decisive, but with death rates seemingly halved (sorta, maybe, kinda) — it does show how crazy it is to ban hydroxychloroquine. It also shows it’s low risk, and with all the conflicting studies out there, that there are a lot of ways to stuff things up.
With 10 million cases around the world it seems a bit incongruous that it’s taken so many months to get a trial this basic done with 2,000 patients. When the world only had 10,000 patients in January we already knew that the three drugs that were “fairly effective” were Remdesivir, Chloroquine and Ritonavir. As far back as February 13, the South Koreans were already recommending hydroxychloroquine and telling us the anti-virals should be “started as soon as possible.” They warned that after ten days, doctors “do not have to start antivirals”. South Korea was the experiment that worked — but we ignored it.
Speaking of slow research, the UK hydroxychloroquine trial that was stopped has restarted again as of three days ago. This is a trial to see if HCQ can prevent coronavirus in 40,000 healthcare workers.
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We discussed the inadequacies of the large Lancet study of hydroxychloroquine supposed used on 96,000 Covid patients from 671 hospitals. It was largely useless because it ignored zinc, wasn’t randomized and was mainly used on people who were already very ill, with a terrible 12% death rate. But it is far worse than that and has now been retracted. The number of deaths listed in Australia was higher than the official Australian tally on April 21. The number of Covid cases in Turkey was 80 times higher than official numbers.
All over the world the study spooked doctors and governments (with WHO help) into stopping the use of HCQ in their large trial across in 17 countries .That trial has since been restarted.
The authors have now retracted the paper after Surgisphere refused to transfer the full dataset “due to confidentiality”.
The Guardian investigated the company that came out of nowhere with this enormous dataset which was used in both The Lancet paper and a New England Medical Journal paper. It turned out to be small, with a handful of employees and that include a science fiction writer, an adult content model, and few scientific qualifications. When The Guardian contacted […]
Remember the Japanese wonder drug Ivermectin that killed Coronavirus in the lab? Some trials on patients in Bangladesh and the US are showing some promise. This is the drug I called “sheep dip” (but which is really more of a cow or horse drench now). It’s famous for stopping River Blindness and saving the eyesight of thousands. It’s also used against roundworms, lungworms, mites, lice, scabies and hornflies, as well as cattle-ticks. So it’s another drug, like hydroxycholoroquine that has been road tested for safety’s sake up the kazoo.
The cost of Ivermectin is around 15c in the third world, and $50 for one round for a human in New York. (But even that is a lot cheaper than a $5000 a day ICU bed.)
As I said — there may come a day when you can cure coronavirus and treat the kids headlice at the same time. Handy.
So it’s good to know some trials are occurring, and even better to know that some doctors are very enthusiastic about the results. In terms of medical clinical trials, these are small. I’m not sure the enthusiasm is matched by the data. I’d only say “it’s not dead yet”. But in […]
“A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture.”
–Caly et al 2020
It’s another day in freaky chemistry — researchers at Monash University found that one of the main components of sheep drench is also very good at reducing Coronavirus, at least in test tubes. Ivermectin’s an unsung hero of the world of biochemistry, called a “Wonder Drug” and a “Blockbuster” because it works against roundworms, lungworms, mites, lice, scabies and hornflies, as well as cattle-ticks. Most importantly, it kills the worm that causes River Blindness, saving the vision of thousands in sub-saharan Africa, and places like Ecuador.
That’s doesn’t mean it will work in vivo — and it may be a month before human trials begin so we can find out.
Possibly, in a few months you might be able to kill off Coronavirus and deworm yourself at the same time.
Though the human experiment is already probably happening in countries where it is being used already and coronavirus is circulating. Surely we can track those cases?
And at least in Australia, unlike Chloroquine — which we don’t have much of — with 70 million sheep I can’t […]
I’ve said from the start that anti-virals were always going to be more useful to us this year than vaccines, which take so long to test and be ready for use. What we really need are anti-virals which also happen to be preapproved and tested and hopefully in mass production. Chloroquine is cheap too, though I doubt Australian stocks of the drug are very high, or that our genius rulers have arranged more. This may be a godsend in Africa where chloroquine use is already high and may reduce the spread of Covid-19 somewhat.
The UK banned export of chloroquine a few weeks ago. Clearly someone there thought it might be useful.
Wang et al reported on Feb 4th that Chloroquine (anti-Malarial) and Remdesivir (anti HIV) may be useful against Coronavirus. They used lab experiments on cells in glass, which had promise. But “in vitro” doesn’t always mean “in vivo”. So I’ve been waiting for some results on people. Early reports were ambiguous. Recently this was hyped as an “Australian cure” which really just meant the start of a proper trial.
There are links to papers and discussion below but I can’t beat this great description explaining how inside the […]
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